The two areas of the UK have moved to tier-3 of lockdown which means the strictest measures in the country.
Over 8.2 million people will be affected as the measures take place from 12.01am on Tuesday for Warrington and 12.01am on Thursday for Nottingham.
Local councillors say they are introducing the harsh lockdown in a bid to curtail and reduce infection rates and “help protect our vulnerable residents”.
Warrington is sandwiched between Liverpool and Manchester, both of which are already in tier 3, along with nearby Lancashire and the Sheffield city region in South Yorkshire.
The new measures mean all pubs and bars must close, unless they are serving “substantial meals”. Alcohol can be served only alongside food.
Non-essential businesses such as casinos and soft-play areas will also be closed.
“Further measures specific to these areas of Nottingham and Nottinghamshire will be announced tomorrow,” councillors for the two areas said.
Infection rates in Warrington are among the highest in the country and continue to rise rapidly, with case rates at 361 people per 100,000 among all age groups – double the England average of 180.6 people per 100,000.
Nottingham city will be in tier 3 as will the surrounding areas of Gedling, Broxtowe and Rushcliffe.
Health Secretary Matt Hancock thanked residents for their “sacrifices” and added: “I want to extend my thanks to each and every one of them for recognising the severity of the situation and sticking to the rules.”
Lilian Greenwood, the Labour MP for Nottingham South, said the government’s communications with local politicians and the public over its tier 3 announcement had been “woeful”.
“It’s more than a week since the prime minister and Matt Hancock said they were talking to Notts about going into tier 3, yet talks didn’t even begin until late on Thursday and MPs weren’t even briefed until Friday morning,” said Greenwood.
“People rightly want to understand why extra restrictions are needed, what the restrictions involve – what are they being asked to do, how will wages and businesses be supported, and what do we need to achieve to come out of tier 3?”
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